[15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. More Info about Chlorthalidone. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. Disclaimer - All information and content on this site are for information and educational purposes only. In Analytical Profiles of Drug Substances, vol. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. This site complies with the HONcode standard for trustworthy health information: verify here. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. Chlorthalidone only comes as a tablet you take by mouth. [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). They are available as follows: NDC 16714-128-01 in bottle of 100 tablets The most common adverse reaction in adults is diarrhea. Brand names: Diuril, Diuril Sodium. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. What is chlortalidone? Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. This medication is used to treat high blood pressure (hypertension). Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. US Brand Name. [1] Some recommend chlortalidone over hydrochlorothiazide. Singer, Jeff M., Michael J. O'Hare, Carl R. Rehm, and John E. Zarembo. The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. Chlorthalidone has a much longer half-life compared to HCTZ (mg/mg) (44 hours, chlorthalidone vs. 12 hours, hydrochlorothiazide) and indapamide is 10 times more potent. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … [1] It is specifically a thiazide-like diuretic. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. Description and Brand Names. Brand names: Hygroton, Thalitone. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Thalitone; Descriptions. National Center for Biotechnology Information. Contraindications. As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. Drug information provided by: IBM Micromedex. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. Chlorthalidone is an oral antihypertensive/diuretic. [5][12] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity. [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … 100 Stones in the urinary system can form in the kidneys and can sometimes travel down towards the bladder to give rise to acute colics. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. Drug class (es): thiazide diuretics. [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. Generic Name: . High Blood Pressure. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. High Blood Pressure. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. Academic Press, 1985. [7][8] While it may be used in pregnancy it is a less preferred option. It is taken by mouth. OH I o+ s NH2 CHLORTHALIDONE 3 1.2 Trade Names Hygroto@ x Regrotoa Hydro-Long Hydroton Igroton Chlorthalidone is also a component of Regrotor@ and Demi-Regroton combination products containing Chlorthalidone in combination with reserpine. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. Anuria. 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