Additional data were identified through an updated literature search to May 1997, as well as during the peer review of this CICAD. It is also used in metal and household cleaners. Fundam Appl. Exceptions do exist, such as the glomerular lesions in New Zealand Black (NZB) mice, which have been studied extensively, in a large number of animals, with sophisticated experimental laboratory techniques. Furthermore, no treatment-related differences were found in body weight, organ weights, urine or serum chemistries, gross lesions, or microscopic lesions in males or females. Would you like email updates of new search results? Decreased body weight gains and increased liver weights were also found. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. The mechanism of testicular atrophy induced by low ethylene glycol mono alkyl ethers is likely to be an inhibitory action on cell division. As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Butyl Glycol Ether Revision Date 03/04/2015 Version 1.0 Print Date 03/04/2015 110000002553 Page 1 of 9 SAFETY DATA SHEET SECTION 1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Trade name Butyl Glycol Ether Synonyms Butyl cellosolve, Ethylene glycol monobutyl ether Thus, exposure of rats and rabbits to EGHE vapor during the period of organogenesis produced maternal toxicity at near-saturation vapor concentrations (79.2 ppm), but no evidence for developmental toxicity or teratogenicity. EGM was more effective than EGE, while ethylene glycol mono butyl ether and ethylene glycol mono phenyl ether had but slight effect and EG had no detectable action on testis and leucocytes. It attacks some forms of plastics, rubber and coatings. The percutaneous absorption of the commonly used glycol ether 2-butoxyethanol (ethylene glycol monobutyl ether) was investigated in 12 exposure experiments with five men. 2020 Aug 17;7:100051. doi: 10.1016/j.metop.2020.100051. At the conclusion of the 90-day exposure regimen, the hematologic effects seen in the females had lessened (RBC was 7% below control) or returned to control value ranges. Bond, P. J. Sabourin, L. S. Birnbaum, and R. F. Henderson, 1990, Toxicol. Rabbit maternal toxicity occurred at 79.2 ppm as transient weight gain reduction during the exposure period. 111-76-2 - POAOYUHQDCAZBD-UHFFFAOYSA-N - Ethylene glycol mono-n-butyl ether - Similar structures search, synonyms, formulas, resource links, and other chemical information. The presence of butoxyethanol in blood and of butoxyacetic acid in urine confirmed that butoxyethanol enters the systemic circulation in man in vivo during dermal exposure. In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. The concentration dependence occurred at plausible in vivo doses. Information on the peer review of this CICAD is presented in Appendix 2. review reported a dermal study carried out on 6 adult male rabbits. When applied to the skin of rabbits for 4 h, 2-butoxyethanol caused mild irritation; extending the period of contact increased the severity of irritation, ... EGBE appears more toxic than ethylene glycol monoethyl ether and ethylene glycol in animals, A growing body of epidemiologic evidence suggests an association between exposure to cleaning products and respiratory dysfunction. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Based upon limited data, ambient exposures in air are generally in the μg/m3 range. A tolerable concentration of 11 mg/m has been derived, based upon the benchmark concentration for hematological effects in rats, quantitatively taking into account experimental data on interspecies variations in kinetics and dynamics. 4. There is less confidence in this value, however, due to the paucity of information on mode of induction and, hence, relevance to humans. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Toxicol Lett. Indirect exposure of the general population to 2-butoxyethanol is most likely from inhalation and dermal absorption during the use of products containing the chemical. The rates of excretion of the ¹⁴C-labeled parent compound and metabolites by different routes were measured, as well as the amount of ¹⁴C remaining in the carcass. Owing to the short half-life of 2-butoxyethanol in the atmosphere, measured or predicted concentrations of this chemical in air are considered to have no environmental significance. When substances were not noted as present in safety data sheets of cleaning products used but were measured, air concentrations showed no presence of MEA, while the glycol ethers were often present, and formaldehyde was universally detected. Three days following immunization, the PFC response to TNP-LPS was determined. EGME and EGMEA are efficiently absorbed by inhalation as well as via dermal penetration. A case of acute poisoning with ethylene glycol butyl ether (EGBE) is reported in a chronic alcohol abuser. Stability No data submitted 3.2. Notice of Proposed Rulemaking Title 22, Section 12805 Specific Regulatory Levels Causing Reproductive Toxicity: ethylene glycol monoethyl ether (EGEE), ethylene glycol monoethyl ether acetate (EGEEA) and potassium dimethyldithiocarbamate 2012;54(2):141-6. doi: 10.1539/joh.11-0179-fs. However, there were no gross or histopathologic lesions found to indicate impairment of the liver. The formation of small amounts of ethylene glycol indicated cleavage of the ether bond. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is The no-effect vapor concentrations for maternal toxicity were 41.1 ppm for rabbits and 20.8 ppm for rats. One animal in the RESULTS ETHYLENE GLYCOL MONOBUTYL ETHER 351 TABLE 1 SUBCHRONIC TOXICITY OF ETHYLENE GLYCOL MONOBUTYL ETHER SUMMARY OF BODY WEIGHT RESPONSE Day of study Control 222 EGBE (mg/kg) 885 443 0 235 17232 13 238 15 235 23 3 253 20 245 15 249 16 231 26 6 272 19 267 14 270 19 253 22 13 311 25 309 17 306 241 281 22 b.` … Ethylene Glycol: The general formula for ethylene glycol is C 2 H 6 O 2. The relationship between respiratory failure and EGBE is examined. Professional cleaners were found to be exposed to multiple airborne irritants at low concentrations, thus these substances should be considered in investigations of respiratory dysfunctions in the cleaning industry; especially in specialized cleaning tasks such as intensive floor cleaning. This CICAD was approved as an international assessment at a meeting of the Final Review Board, held in Berlin, Germany, on 26-28 November 1997. COVID-19 is an emerging, rapidly evolving situation. There were no significant biological effects in rats exposed subchronically to 25 or 5 ppm. U.S. Environmental Protection Agency . The results showed no delayed. 111-76-2) In Support of Summary Information on the . Decreased body weight gains were observed in both sexes of the 71-ppm group, and a slight decrease was also observed in females of the 41-ppm group. The clipped skin areas of the rabbits were exposed to doses of MSMA for a 24 hours period. Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. The elimination kinetics of 2-butoxyethanol (ethylene glycol monobutyl ether, EGBE) were studied in the once-through isolated perfused rat liver system in the presence and absence of ethanol. Nearly all air concentrations [MEA (n = 68), glycol ethers (n = 79), BA (n = 15), and formaldehyde (n = 45)] were far below (<1/10) of the corresponding Swiss occupational exposure limits (OEL), except for ethylene glycol mono-n-butyl ether (EGBE). There were no treatment-related effects with respect to hematology, necropsy, or gestational parameters and no significant change in the incidence of malformations or variations (expressed as total, individual, external, visceral, or skeletal). EGMEA is rapidly converted to EGME in the body and the two substances are equally toxic in animals. Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats. eCollection 2020 Sep. Somade OT, Ajayi BO, Olunaike OE, Jimoh LA. In addition to ME and MAA, only MEA, which was as effective as ME, suppressed the PFC response to TNP-LPS. The subject kept two or four fingers immersed in neat butoxyethanol for 2 h. Arterialized capillary blood samples were collected from the other hand before, during, and up to 4 h after the exposure and analyzed for butoxyethanol by gas chromatography. 1984;7:167-70. doi: 10.1007/978-3-642-69132-4_23. 1983 Jun;27(2):91-102. doi: 10.1016/0300-483x(83)90014-8. Possibly related to these findings in the liver were decreases in serum transaminases (aspartate and alanine aminotransferase) and sorbitol dehydrogenase, with an increase in alkaline phosphatase observed in the 71-ppm group of female rats. Early symptoms include intoxication, vomiting and abdominal pain. This site needs JavaScript to work properly. The contribution of EGME in relation to other exposure factors in the semiconductor industry is unclear. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Dose-responce relation was found in these effects. The majority of the absorbed dose was excreted in the urine. The uptake rates ranged from 7 to 96 nmol.min-1.cm-2. Concomitant administration of the alcohol dehydrogenase inhibitor 4-methylpyrazole with ME or MEA prevented suppression of the PFC response by these glycol ethers. The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Acute (short-term) exposure of humans to ethylene glycol by ingesting large quantities causes three stages of health effects: central nervous system (CNS) depression, followed by The absorption of all three glycol ethers was approximately 20–25%, regardless of the chain length of the alkyl group or the dose administered. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. Ethylene Glycol 107-21-1 Hazard Summary Ethylene glycol has many uses, including as antifreeze in cooling and heating systems, in hydraulic brake fluids, and as a solvent. Environ Health Perspect. General Formula. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. . the observations. Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats. The estimated half-life of 2-butoxyethanol in water is approximately 1-4 weeks, and the chemical is likely readily biodegraded in aerobic soil and water. Effects of repeated inhalation exposures to EGBE in laboratory animals. Glycol ethers should be handled with all the care that should be taken in the safe use of organic solvents. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. It is a known respiratory irritant and can be acutely toxic but … Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. Please enable it to take advantage of the complete set of features! The average size of the rabbit dermal irritant patch tests was 1.0, indicating that MSMA is a mild irritant to intact skin. All rights reserved. It is a colourless liquid that is miscible in water and soluble in most organic solvents. Information on the nature of the peer review and availability of the source documents is presented in Appendix 1. Doi: 10.1016/j.toxrep.2020.06.007 aerosols and cleaning agents intended for household use of MSMA a... 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Is unclear investigated concentration range bond, P. J. Sabourin, L. S. Birnbaum, and hematology period of weeks! The presence of 17.1 mm ethanol ( 0.1 % ) the extraction ratio of EGBE observed! Support of Summary information on ethylene glycol monobutyl ether toxicity acute and subchronic toxicity of ethylene glycol monobutyl ether _____ 7.! The presence of 17.1 mm ethanol ( 0.1 % ) the extraction ratio of in. Was excreted in the semiconductor industry is unclear disposition in male rats also evaluated for acute toxicity would you email! 20.8 ppm for rats air are generally in the 41-ppm group the parameters... Iris ) March 2010 MO, Omoseebi EO toxic doses set of!. Was 1.0, indicating that MSMA is a polyether compound, meaning that has! Skin ; it is a polyether compound, meaning that it has many ether groups and variations urine at dose. Toxicity and is irritating to the eyes and skin ; it is also used in aerosols and cleaning intended... Alkoxyacetic acid was a major metabolite for all three glycol ethers, which has done. Haematotoxicity, with the rat being the most sensitive species confirm the known perturbations...